Phentermine. Know of only one prospective randomized controlled trial, which lasted more than 6 months, which assessed the effectiveness of phentermine for weight loss. In this study, published in 1968, attended by 108 women with obesity therapy which consisted of a low-calorie diet (1000 kcal / day) and a daily intake of phentermine or phentermine and placebo interleaved in a month, or only placebo for 36 weeks . Completed the study 64 patients. In the groups receiving only phentermine or phentermine and placebo, weight reduction was more pronounced (13% of baseline) than in the group receiving only placebo (5% of baseline body weight). Side effects of phentermine. Most frequently observed side effects such as dry mouth, insomnia and constipation, which is associated with sympathomimetic drug activity. Although the substances possessing sympathomimetic activity may contribute to high blood pressure and heart rate, these effects while taking phentermine is not observed. Journal of attending physician, ¹ 02/2006 AY Runihin. Modern approaches to treating obesity

   There are many medications that can reduce body weight, but to date only three drugs officially recommended for the treatment of obesity as a means of choice - phentermine, sibutramine and orlistat. Phentermine (ionamin, Adipex, fastin) 60% of patients reduced the weight by more than 5%, which was confirmed in a randomized, placebo-controlled studies. In the treatment with this drug is not obtained reliable data on the possibility of its beneficial effect on the severity of dyslipidemia, hyperglycemia and other complications of obesity. The short form of phentermine is prescribed three times a day for 30 minutes before eating. Retardnye form of phentermine take 1 every day before breakfast. Phentermine is a centrally acting drug